Medical and Technological approach for creating the guideline of risk prediction of aortic aneurysm rupture

2016 Fiscal Year Final Research Report

• Project/Area Number: 26462101
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Cardiovascular surgery
• Research Institution: The University of Tokyo
• Principal Investigator: Hoshina Katsuyuki 東京大学, 医学部附属病院, 講師 (90571761)
• Research Collaborator: OHSHIMA Marie 東京大学, 大学院情報学環, 教授 (40242127) ; YAMAMOTO Sota 芝浦工業大学, 工学部, 教授 (80293653) ; YAMAMOTO Kota 東京大学, 医学部附属病院, 助教 (00753542)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: simulation / aortic aneurysm / rupture / stress

Outline of Final Research Achievements

We have analyzed the fragility (rupture risk) of the aortic aneurysm with our original model. Saccular aneurysm is known to have potential risk of rupture, but the definition of “saccular” has not been determined. We put the hypothetical ellipse on the protruded aneurysm from the aorta, and revealed that the horizontally long ellipse and the vertically long with smaller fillet radius are the factors relating to the rupture risk and concluded these are important factors contribute to the definition of “saccular”. Although we used these definition on the thoracic aortic aneurysm cases by using the enlargement rate, we were not able to reveal the clear association clinically. Herein, we collected rupture cases of abdominal aortic aneurysms and analyzed them via propensity matching comparing to the control group in our institutes. Two factors, vertically long and horizontally long with small fillet, showed strong association with the rupture.

Free Research Field

Vascular Surgery