Fetal lung fragments implantation into fibrotic lung of a pig model

2016 Fiscal Year Final Research Report

• Project/Area Number: 26462127
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Respiratory surgery
• Research Institution: Kochi National Hospital (2016); The University of Tokushima (2014-2015)
• Principal Investigator: SAKIYAMA Shoji 独立行政法人国立病院機構高知病院(臨床研究部), 副院長室, 副院長 (60291986)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 肺の再生 / 胎生期肺 / 肺組織移植 / 肺線維症 / 豚 / ラット / ステロイド

Outline of Final Research Achievements

One of the approaches to lung regeneration and repair, we have noticed to use fetal lung tissues having great potential to further grow and differentiate, and made an experimental model. In the research of fetal lung tissues implantation into normal adult lungs, we showed that implanted fetal tissues were able to live and grow in adult lung using mouse, rat and pig model. The speed of differentiation and growth of implanted fetal tissues dependents on the kind. Speed of the growth and differentiation is slower in the pigs than the rodents. Administration of glucocorticoid to recipients after fetal lung tissues implantation facilitated the development and growth of implanted fetal lung tissues. The quantity of elastin in implanted fetal tissues was increased by glucocorticoid. These effects depended on the duration of the glucocorticoid use. Although fetal lung tissue could survive and differentiate in the fibrotic lung in the rats, in the pig model the matter have not been proved yet.

Free Research Field

呼吸器外科学