2016 Fiscal Year Final Research Report
Search for new therapeutic targets of the tobacco-related lung cancer
| Project/Area Number |
26462142
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Respiratory surgery
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| Research Institution | Chiba Cancer Center (Research Institute) |
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Principal Investigator |
MORIYA Yasumitsu 千葉県がんセンター(研究所), がんゲノムセンター, 客員研究員 (90375692)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 肺癌 / ゲノム / マイクロRNA / 遺伝子 / 外科 |
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| Outline of Final Research Achievements |
Squamous cell carcinoma (SqCC) is second major histological subtype of lung cancer. Unlike in the case of lung adenocarcinoma (Ad), SqCC has only few molecular target drugs. In the mature microRNA(miR) fragments, 34 miRs were identified as the candidates especially for SqCC distinguished from Ad. Furthermore, four miRs were up regulated in amplified regions and independently associated with poor prognosis in SqCC. Moreover, those who had the tumor with high expression in three of four miRs simultaneously showed the worst prognosis. To explore miR-mRNA network, we also predicted the target genes for each miRs. MicroRNA will regulate target molecules related to carcinogenesis and malignancy in SqCC.
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| Free Research Field |
医歯薬学
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