Role of selective estrogen receptor modulators on cerebrovascular diseases

2016 Fiscal Year Final Research Report

• Project/Area Number: 26462159
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Neurosurgery
• Research Institution: 独立行政法人国立病院機構四国こどもとおとなの医療センター(臨床研究部(成育)、臨床研究部(循環器)) (2015-2016); The University of Tokushima (2014)
• Principal Investigator: Kuwayama Kazuyuki 独立行政法人国立病院機構四国こどもとおとなの医療センター(臨床研究部(成育)、臨, 臨床研究部, 脳神経外科医長 (50614236)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 脳血管病 / エストロゲン受容体α/β / エストロゲン受容体調節薬

Outline of Final Research Achievements

Severe ischemic stroke and subarachnoid hemorrhage due to rupture of cerebral aneurysms are catastrophic and poor prognosis. Hormonal replacement therapy does not necessarily result in the good outcome. Elsewhere we demonstrated the beneficial role of estrogen receptors (ERs) against brain vascular diseases. In this study, we focused on the role of ERs. Since the affinity of estrogen to ERα is 1000 times higher than ERβ, ERα acts mainly under its presence. ERβ is thought to compensate when ERα is downregulated. We treated with a selective ER modulator (SERM) approved for osteoporosis in the cerebral aneurysm model rats. SERM was protective against cerebral aneurysm rupture; the inhibition of a cytokine, IL-1β and a vascular degradation molecule, MMP-9 by SERM was attributable to the efficacy. We are planning to identify the risk factors associated with the expression of cytokine and vascular degradation molecules and to clarify the role of SERM against cerebral ischemia.

Free Research Field

脳血管障害