2016 Fiscal Year Final Research Report
Nerve regeneration through A vessel-containing nerve conduit implanted with bone marrow stromal cells and decellularized allogenic nerve matrix
| Project/Area Number |
26462240
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Kindai University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | vascular bundle / stem cell / allogenic nerve / artificial nerve conduit |
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| Outline of Final Research Achievements |
Nerve regeneration in a novel artificial nerve conduit implanted with a vascular bundle and decellularized allogenic nerve matrix seeded with bone marrow stromal cells was investigated in comparison with that in an autologous nerve graft, using a rat sciatic nerve model with a 20mm gap. Gait analysis at 24 weeks showed that in the conduit group, the area of the foot print and contact pressure of the operated hind limb were significantly greater than that in the autograft group. The conduit group was superior to the autograft group, regarding the amplitude of the compound muscle action potential in the pedal adductor muscle and the motor nerve conduction velocity. In the conduit group, the number of the myelinated axons was smaller and the diameter of the nerve fibers was larger when compared with the autograft group. Nerve regeneration through this nerve conduit was compatible with that through an autogenous nerve graft.
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| Free Research Field |
peripheral nerve surgery
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