2016 Fiscal Year Final Research Report
Functional role of Syndecan-4 in the process of osteochondral repair
| Project/Area Number |
26462257
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Hokkaido University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 整形外科 / 軟骨損傷 / 軟骨再生 / 骨軟骨修復 / 動物モデル |
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| Outline of Final Research Achievements |
We successfully developed novel osteochondral repair model by using young C57Bl/6 mice（Matsuoka M, Onodera T et al., Tissue Eng. 2015）。This novel animal model made us to clarify the cartilage repair mechanisms in glycosphingolipid depletion mice（Matsuoka M, Onodera T et al., Sci Rep. 2017）。In addition, we applied this animal model to Syndecan-4 knockout mice. Surprisingly, osteochondral repair in Syndecan-4 knockout mice is enhanced compare with wildtype mice.
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| Free Research Field |
整形外科
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