2016 Fiscal Year Final Research Report
Development of diagnosis and elucidation of the onset mechanism for hypermobility type of Ehlers-Danlos syndrome
Project/Area Number |
26462296
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Orthopaedic surgery
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Research Institution | Shimane University |
Principal Investigator |
|
Project Period (FY) |
2014-04-01 – 2017-03-31
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Keywords | エーラス・ダンロス症候群 / テネイシンX / 関節可動亢進 / 過剰運動症候群 / プロテオミクス解析 / 質量分析 / フィブリン/コラーゲンゲル |
Outline of Final Research Achievements |
Hypermobility type of Ehlers-Danlos syndrome (EDS) is a heritable connective tissue disorder characterized by joint hypermobility. We developed a method for quantification of serum TNX, one of the causative genes of hypermobility type of EDS, using nano-liquid chromatography tandem mass spectrometry. It was revealed that serum concentrations of TNX of healthy individuals were quantified as an average of 144 ng/ml. Furthermore, in order to identify potential serum biomarkers for hypermobility type of EDS, we examined proteins with differential levels in sera from the patients by proteomic analyses. We identified 6 proteins involved in the complement system as increased proteins in sera from the patients.
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Free Research Field |
医歯薬学
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