Investigatation of chronic inflammation in bone by gastro-intestinal-bone axis

2017 Fiscal Year Final Research Report

• Project/Area Number: 26462316
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Orthopaedic surgery
• Research Institution: Wakayama Medical University
• Principal Investigator: Mikitaka Iguchi 和歌山県立医科大学, 医学部, 講師 (40336889)
• Co-Investigator(Kenkyū-buntansha): 山本 悠太 和歌山県立医科大学, 医学部, 講師 (00580672) ; 一瀬 雅夫 和歌山県立医科大学, 医学部, 教授 (50143425) ; 上山 敬司 和歌山県立医科大学, 医学部, 教授 (50264875) ; 上田 和樹 和歌山県立医科大学, 医学部, 博士研究員 (50405437) ; 鶴尾 吉宏 徳島大学, 大学院医歯薬学研究部(医学系), 教授 (90207449)
• Project Period (FY): 2014-04-01 – 2018-03-31
• Keywords: 胃切除 / 骨代謝異常 / 炎症

Outline of Final Research Achievements

We reported the abnormality of bone metabolism in gastrectomized rats. However, the effects of gastrectomy in multiple organs had not been clear. We examined the effect of gastrectomy on rat livers with analysis of gene expression, biochemistry, and histological changes.
Microarray analysis identified 573 differential expressed genes in gastrectomized rat liver, and pathway analysis indicated statistically relationship between these genes and steroid signaling and lipid metabolism. In gastrectomized rats, serum ALT was increased, and small droplets were observed in hepatocyte. Furthermore, lethal events were significantly happened in gastrectomy rats.
The case reports about liver dysfunction after gastrectomy have been reported, this study may explain the mechanisms of these cases.

Free Research Field

消化器疾患