2016 Fiscal Year Final Research Report
The strategy of protection against ischemic spinal cord injury by development of perivertebral collateral circulation through segmental artery ligation.
| Project/Area Number |
26462337
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Anesthesiology
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| Research Institution | Yamaguchi University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 脊髄虚血 / 対麻痺 / 脳・神経 / 麻酔科学 / 胸腹部大動脈瘤 / 周術期管理 |
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| Outline of Final Research Achievements |
In this study, we investigated whether segmental artery ligation protects against ischemic spinal cord injury by development of perivertebral collateral circulation in rabbits. When one or two segmental arteries near the renal artery were sacrificed, the spinal blood flow hardly changed and postoperative paraplegia did not occur. Spinal cord ischemia was induced by occluding the abdominal aorta for 15 min, and after 7 days of sacrifice involving one or two segmental arteries near the renal artery. The spinal blood flow of the rabbits that underwent segmental artery sacrifice decreased similarly to that of the rabbits that did not undergo segmental artery sacrifice. The spinal cord was not protected by segmental artery sacrifice in rabbits.
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| Free Research Field |
麻酔科学
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