2016 Fiscal Year Final Research Report
Cardioprotective effects of phosphodiesterase-3 inhibitor in hyperglycemic swine
| Project/Area Number |
26462338
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Anesthesiology
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| Research Institution | Nagasaki University |
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Principal Investigator |
HARA Tetsuya 長崎大学, 医歯薬学総合研究科(医学系), 教授 (50304952)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
|
| Keywords | 虚血再灌流傷害 / 気絶心筋 / オルプリノン / 高血糖 / コンディショニング |
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| Outline of Final Research Achievements |
Olprinone, phosphodiesterase-3 inhibitor, improves the contractile functional recovery against stunned myocardium in hyperglycemic swine. Activation of phosphatidylinositol-3 kinase/Akt and protein kinase A would be involved in this cardioprotective mechanism.
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| Free Research Field |
麻酔科学
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