Ischemic myocardial protection strategy by the balanced anesthesia-Examination by the cardiopulmonary resuscitation model-

2017 Fiscal Year Final Research Report

• Project/Area Number: 26462363
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Anesthesiology
• Research Institution: Nagasaki University
• Principal Investigator: YOSHITOMI Osamu 長崎大学, 病院(医学系), 准教授 (30380926)
• Project Period (FY): 2014-04-01 – 2018-03-31
• Keywords: 虚血再灌流障害 / 気絶心筋

Outline of Final Research Achievements

Using laboratory animal models put under general anesthesia, we examined protection effect for the myocardial and hepatic ischemic reperfusion injury of inhalation anesthetic, inotropic agent or antidiabetic drug. Also, we examined effect for the myocardial ischemic reperfusion injury of acute hypercapnea.
These studies suggest that PDE Ⅲ inhibitor milrinone and glucagon-like peptide-1 receptor agonist exert cardioprotective effects, inhalation anesthetic sevoflurane exert hepaticprotective effects. However, suggested that the preconditioning of acute hypercapnea did not affect the myocardial ischemia reperfusion injury.

Free Research Field

周術期管理