Neuropeptide in the rat oviduct: Implications for association with stress

2016 Fiscal Year Final Research Report

• Project/Area Number: 26462486
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Obstetrics and gynecology
• Research Institution: Mie University
• Principal Investigator: Ida-Eto Michiru (伊田みちる) 三重大学, 医学系研究科, 助教 (80393148)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 卵管 / 神経ペプチド / ラット / ストレス / 視床下部 / 下垂体

Outline of Final Research Achievements

The relationship between emotional stress and infertility has been widely accepted. Manserin is distributed in the neuroendocrine system and its expression in the adrenal gland is stress dependent. Recently, I found the localization of manserin in the oviduct of female rats. In this study, I investigated the relationship between manserin and estrus cycle, development or stress condition.
Manserin immunoreactivity was detected on the surface of the oviduct at postnatal day 14. Localization of manserin in the oviduct was not changed with estrus cycle or stress. Manserin was colocalized with the dopaminergic neuron marker, tyrosine hydroxylase, at the arcuate nucleus of hypothalamus. These results suggest that manserin may be involved in the regulation of hypothalamus-pituitary-gonad axis.

Free Research Field

神経科学、解剖学