2016 Fiscal Year Final Research Report
Novel medical therapy targeted NFkB for the infertile patients with endometriosis
| Project/Area Number |
26462490
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Tottori University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 子宮内膜症 / 炎症 / マウスモデル |
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| Outline of Final Research Achievements |
Local and chronic inflammatory reaction in the peritoneal environment is considered the contributing factors in the pathogenesis of the infertile patients with endometriosis. The inflammatory mediators, such as bacterial endotoxin, LPS (lipopolysaccharide), in the menstrual or peritoneal fluid, can activate the innate immune cells. A mouse endometriosis model was established by transplanting autologous endometrial tissue. LPS increased total number, size, and mRNA expression of the inflammation-related factors in murine endometriosis-like lesions, as human endometriotic tissues in the early stage.Treatment with a NFkB inhibitor negated these LPS-induced effects. LPS-induced pelvic inflammation status enhanced the development of murine endometriosis-like lesions via NFkB pathway.These data can be a molecular basis with regard to the strategy of novel treatment for the infertile patients with endometriosis.
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| Free Research Field |
産婦人科学
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