2017 Fiscal Year Final Research Report
Functional analysis of M cells in pharyngeal tonsil
| Project/Area Number |
26462554
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Kanazawa University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2018-03-31
|
| Keywords | M細胞 |
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| Outline of Final Research Achievements |
Some infants develop repetitive otitis media as pharyngeal tonsils are exposed to drug resistant bacteria. This maximum factor is thought to be the immunocompetence of the host side. M cells take up foreign antigens such as pathogenic microorganisms in nasopharyngeal related lymphoid tissues and play an important role in mucosal immunity. This M cell was considered to be an important internal factor. However,the hypothesis that "Inadequate quantitative or qualitative status of M cells in the pharyngeal tonsils decreases antigen uptake capacity and decreases the function of early immunity, leading to upper airway refractory infection and repetitive otitis media" could not be proved.
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| Free Research Field |
耳鼻咽喉科・頭頸部外科
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