2016 Fiscal Year Final Research Report
Endolymph control system of the endolympatic sac and the stria vascularis
| Project/Area Number |
26462559
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Kagawa University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 内耳 / 内リンパ嚢 / イオン輸送 / イメージング / イオンイメージング / 血管条 / 減塩治療 / アルドステロン |
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| Outline of Final Research Achievements |
A low-salt diet was an effective treatment for patients with Meniere’s disease. This treatment will have a greater effect, when sodium intake is reduced to less than 3 g/day. A low-salt diet may induce an increase in the plasma aldosterone concentration that can activate ion transport and absorbing endolymph in the endolymphatic sac.
We also detected the expression of tricellulin, which is involved in controlling intracellular ion transport, in endolymphatic sac epithelia. Furthermore, we developed a new 3D imaging system for the endolymphatic sac.
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| Free Research Field |
耳科学
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