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2016 Fiscal Year Final Research Report

Elucidation of mechansim to form pre-metastatic niche in nasopharyngeal carcinoma and development of exosome for its treatment

Research Project

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Project/Area Number 26462597
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Otorhinolaryngology
Research InstitutionKanazawa University

Principal Investigator

Naohiro Wakisaka  金沢大学, 医学系, 准教授 (70377414)

Co-Investigator(Renkei-kenkyūsha) YOSHIZAKI Tomokazu  金沢大学, 医学系, 教授 (70262582)
MURONO Shigeyuki  福島県立医科大学, 医学部, 教授 (20345622)
KONDO Satoru  金沢大学, 附属病院, 助教 (70436822)
ENDO Kazuhira  金沢大学, 附属病院, 助教 (30547154)
TSUJI Akira  金沢大学, 医学系, 協力研究員 (70632652)
Project Period (FY) 2014-04-01 – 2017-03-31
Keywords上咽頭癌 / EBV / EBERs / miR-BARTs / エクソソーム / Argonaute 2
Outline of Final Research Achievements

EBV-associated oncoprotein, LMP1, was not detected in nasopaheryngeal carcinoma (NPC) cell line, C666.1,-derived exosomes. In contrast, EBV-associated RNAs, such as EBERs and BART-miRNAs, was easily detected in the exosomes.
One of BART-miRNAs, miR-BART17-5p, was secreted in extra-ordinally pathway, but in exsosome-independent pathway. The miRNA would be expected as novel therapeutic target of NPC.

Free Research Field

頭頸部癌

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Published: 2018-03-22  

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