Mechanism of subepithelial invasion in the superficial pharyngeal cancer

2017 Fiscal Year Final Research Report

• Project/Area Number: 26462602
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Otorhinolaryngology
• Research Institution: Kyoto University
• Principal Investigator: Tateya Ichiro 京都大学, 医学研究科, 講師 (20526363)
• Co-Investigator(Kenkyū-buntansha): 平野 滋 京都府立医科大学, 医学(系)研究科(研究院), 教授 (10303827) ; 武藤 学 京都大学, 医学研究科, 教授 (40360698) ; 北村 守正 京都大学, 医学研究科, 助教 (60543262) ; 岸本 曜 京都大学, 医学研究科, 特定病院助教 (80700517) ; 森田 真美 京都大学, 医学研究科, 医員 (90637597) ; 石川 征司 京都大学, 医学(系)研究科(研究院), その他 (70570159)
• Project Period (FY): 2014-04-01 – 2018-03-31
• Keywords: 咽頭癌 / 表在癌 / 上皮下浸潤 / アラキドン酸 / イメージングマススペクトロメトリー

Outline of Final Research Achievements

Superficial-type pharyngeal squamous cell carcinoma (STPSCC) is defined as carcinoma in situ or microinvasive squamous cel lcarcinoma without invasion to the muscular layer. Imaging mass spectrometry (IMS) is suitable for phospholipid analysis because this technique can distinguish even fatty acid compositions and was conducted to elucidate the distribution of PC species in STPSCC tissues. STPSCC tissue sections from five patients were analyzed, and we found that three kinds of phosphatidylcholine species containing arachidonic acid were increased in the subepithelial invasive region. These results may be associated with the invasion mechanism of hypopharyngeal carcinoma.

Free Research Field

耳鼻咽喉科学