brain damage after heat stroke in mice

2017 Fiscal Year Final Research Report

• Project/Area Number: 26462769
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Emergency medicine
• Research Institution: Showa University (2016-2017); Jikei University School of Medicine (2014-2015)
• Principal Investigator: Dohi Kenji 昭和大学, 医学部, 教授 (20301509)
• Co-Investigator(Kenkyū-buntansha): 大滝 博和 昭和大学, 医学部, 准教授 (20349062) ; 小川 武希 東京慈恵会医科大学, 医学部, 教授 (90119769) ; 宮本 和幸 昭和大学, 医学部, 助教 (80555087)
• Project Period (FY): 2014-04-01 – 2018-03-31
• Keywords: 熱中症 / 水素水 / モデル / マウス

Outline of Final Research Achievements

The purpose of this project was to clarify the pathophysiology of neuroinflammation in mice heat stroke model. We developed mice heat stroke model which was not established. We also clarified the beneficial effect of the mineral supplement in heat stroke. The evaluation of the oxidative stress in heat stroke and the development of the new treatment using the hydrogen water is undergoing. We also found that heat stress cause intestinal tract damage. Basis of these results, we will clarify the relations with neuroinflammation and systemic inflammation in heat stroke.

Free Research Field

救急医学