Immunoparalysis and analysis of hematopoietic stem cell in sepsis:a trial of regenerative immunoactivity by bone-marrow transplantation

2017 Fiscal Year Final Research Report

• Project/Area Number: 26462771
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Emergency medicine
• Research Institution: Nagoya City University (2015-2017); Fujita Health University (2014)
• Principal Investigator: Hattori Tomonori 名古屋市立大学, 大学院医学研究科, 教授 (90363936)
• Co-Investigator(Kenkyū-buntansha): 武山 直志 愛知医科大学, 医学部, 准教授 (00155053) ; 秦 龍二 藤田保健衛生大学, 医学部, 教授 (90258153)
• Project Period (FY): 2014-04-01 – 2018-03-31
• Keywords: 敗血症 / 免疫不全 / 骨髄移植

Outline of Final Research Achievements

In septic shock patients, serial blood samples were obtained on days 1, 3, and 7 after the onset of shock, and immune cell subsets and receptor expression were characterized. A decrease of immunoactivity of T cells and monocyte were observed in the early stage of septic shock. Significant lymphopenia persisted for at least 7 days following the onset of septic shock. Normalization of immunodysfunctions was observed by day 7, except in patients who died. Our findings emphasize the importance of normal lymphocyte function for recovery from septic shock. These results indicate that the regeneration of the immunoparalytic state by bone-marrow transplantation, can be potentially effective therapy for recovery from septic shock.

Free Research Field

救急医療、集中治療