The mechanisms of antibiotic tolerance focusing on intracellular signaling substance c-di-GMP.

2017 Fiscal Year Final Research Report

• Project/Area Number: 26462787
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Morphological basic dentistry
• Research Institution: The University of Tokushima
• Principal Investigator: MURAKAMI Keiji 徳島大学, 大学院医歯薬学研究部(歯学系), 准教授 (10335804)
• Co-Investigator(Kenkyū-buntansha): 弘田 克彦 徳島大学, 大学院医歯薬学研究部(歯学系), 准教授 (60199130) ; 三宅 洋一郎 徳島大学, 大学院医歯薬学研究部(歯学系), 教授 (80136093)
• Co-Investigator(Renkei-kenkyūsha): KARIYAMA Reiko 岡山学院大学, 人間生活学部, 教授 (40112148)
• Research Collaborator: AMOH Takashi 徳島大学, 大学院医歯薬学研究部, 助教 (00803545)
• Project Period (FY): 2014-04-01 – 2018-03-31
• Keywords: 緑膿菌 / 抗菌薬抵抗性 / c-di-GMP / 付着

Outline of Final Research Achievements

Floating bacteria attach to the solid surface and form biofilms after produceing extracellular polysaccharides. Infectious diseases caused by biofilms are chronic and refractory, but the cause is considered to be antibiotic tolerance. In this study, we showed that the psl genes, which are activated by surface adherence through elevated c-di-GMP levels, confer antibiotic tolerance.

Free Research Field

細菌学