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2016 Fiscal Year Final Research Report

Treatment of vertical root fracture using hybrid between TCP resin composits and nanohydroxyapatite collagen

Research Project

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Project/Area Number 26462867
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Conservative dentistry
Research InstitutionHokkaido University

Principal Investigator

SUGAYA Tsutomu  北海道大学, 歯学研究科, 准教授 (10211301)

Project Period (FY) 2014-04-01 – 2017-03-31
Keywords垂直歯根破折 / 樹脂含侵層 / BMP / 硬組織再生 / レジン
Outline of Final Research Achievements

Induction of ectopic hard tissue formation and resin-bonding affinity using αTCP-4META/MMA-TBB resin composits and ascorbic acid/copper chloride or EDC crosslinked nanohydroxyapatite/collagen complex (nHAC) impregnated with BMP-2 were examined in vitro and in vivo in order to improve the clinical outcome of vertical root fracture treatent.
As results, a hybrid layer was observed at the interface between resin and bone in both optical microscope and SEM observation, and direct resin-bone contact was observed without connective tissue intervention, when nHAC crosslinked with ascorbic acid/copper chloride was adhered to resin and impregnated with BMP-2 and implanted into connective tissue.

Free Research Field

歯周病学

URL: 

Published: 2018-03-22  

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