Molecular mechanism of sphingosine-1-phosphate-modulated MSC differentiation for hard tissue regenerative therapy

2016 Fiscal Year Final Research Report

• Project/Area Number: 26462886
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Conservative dentistry
• Research Institution: Fukuoka Dental College
• Principal Investigator: Matsuzaki Etsuko 福岡歯科大学, 口腔歯学部, 講師 (20432924)
• Research Collaborator: Higashi Yoko 九州大学, 歯学研究科(研究院), 医員 (90755042) ; Higashi Katsumasa 九州大学, 歯学研究科(研究院), 医員 (90778846)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 骨 / 分化 / スフィンゴシン-1-リン酸 / 未分化間葉系幹細胞

Outline of Final Research Achievements

Mesenchymal stem cells (MSC) in periodontal ligament or dental pulp play a crucial role in periodontal tissue regeneration or hard tissue regeneration. Therefore, to regulate the commitment to MSC differentiation is important for regenerative treatment.
S1P regulates many cellular responses, such as migration, growth, and differentiation. In this study, we investigated the mechanism of S1P-modulated MSC differentiation.
We found that S1P enhances Wnt5a expression, which leads to the trigger of osteogenic differentiation in MSC. Furthermore, we found that S1P/S1PR2 signaling promotes osteogenic differentiation and bone formation in vivo. Our results suggest a potential beneficial role of this compound for hard tissue regeneration.

Free Research Field

歯科保存学