2016 Fiscal Year Final Research Report
Bone Augmentation Strategy with epigenetics small molecules
| Project/Area Number |
26462915
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Prosthodontics/ Dental materials science and
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| Research Institution | Niigata University |
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Principal Investigator |
AKIBA YOSUKE 新潟大学, 医歯学総合病院, 講師 (70547512)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | エピジェネティクス / 骨増生 |
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| Outline of Final Research Achievements |
The aim of this study was to evaluate epigenetics small molecule effect on acceleration of bone formation through regulation of inflammation, cell migration, and osteoblast differentiation. This study would help to establish bone augmentation therapy with multiple approach such as increasing of cell recruitment, vascularization, and mineralization. Valproic acid which had HDACi effect was used as epigenetic small molecule. VPA treatment with osteogenic differentiation stimulation showed significant increase in expressions of osteogenic marker gene compare to the osteogenic differentiation stimulation alone. VPA treatment also increased cell recruitment related gene and vascularization related gene expressions.
VPA treated cell transplantation to the calvarias cavity showed more bone formation than control cell transplantation.
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| Free Research Field |
歯科補綴学
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