2016 Fiscal Year Final Research Report
Development of novel bone graft materials by combining scaffold-free cell construct and freeze dry technique
| Project/Area Number |
26462969
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Dental engineering/Regenerative dentistry
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| Research Institution | Osaka University |
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Principal Investigator |
|
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| Research Collaborator |
YOSHIMOTO Itsumi
|
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| Project Period (FY) |
2014-04-01 – 2017-03-31
|
| Keywords | 生体材料学 / 再生歯学 / 骨補填材 / 細胞集合体 |
|---|
| Outline of Final Research Achievements |
The objective of this study was to develop the bone graft materials by combining scaffold-free cell construct fabrication system and freeze dry technique. With the usage of appropriate pretreatments, bone-like constructs, fabricated through osteoinduction of aggregate of bone marrow stromal cells, were able to maintain extracellular matrix and mineralized matrices even after being freeze-dried. The freeze-dried bone like constructs achieved in this study are expected to be used as a useful biomaterial for bone regenerative medicine.
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| Free Research Field |
組織工学
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