Expression and role of cancer stem cell marker in invasion and metastasis of oral cancer

2017 Fiscal Year Final Research Report

• Project/Area Number: 26463050
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Surgical dentistry
• Research Institution: Kagoshima University
• Principal Investigator: ISHIDA Takayuki 鹿児島大学, 医歯学域附属病院, 助教 (20404501)
• Co-Investigator(Kenkyū-buntansha): 吉村 卓也 鹿児島大学, 医歯学域附属病院, 助教 (30726758) ; 中村 典史 鹿児島大学, 医歯学域歯学系, 教授 (60217875) ; 久米 健一 鹿児島大学, 医歯学域附属病院, 助教 (60650067) ; 比地岡 浩志 鹿児島大学, 医歯学域附属病院, 講師 (70305150)
• Project Period (FY): 2014-04-01 – 2018-03-31
• Keywords: がん幹細胞 / 口腔扁平上皮癌

Outline of Final Research Achievements

Cancer stem cells are attracting attention as a factor showing chemoradiotherapy resistance of cancer tissue, but in recent years cancer cells have acquired cancer stem cell-like properties by causing epithelial mesenchymal transition (EMT). It is pointed out that the metastatic potential may be enhanced. We induced EMT by introducing snail into oral cancer cell line HSC4 and confirmed that the expression level of mRNA of stem cell markers in the cell line increases. These findings suggested that induction of EMT in oral cancer cell lines would acquire cancer stem cell-like properties.

Free Research Field

口腔外科