Elucidation of the molecular mechanisms of the periodontal tissue repair

2016 Fiscal Year Final Research Report

• Project/Area Number: 26463104
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Orthodontics/Pediatric dentistry
• Research Institution: Okayama University (2015-2016); Matsumoto Dental University (2014)
• Principal Investigator: Nakano Keisuke 岡山大学, 医歯薬学総合研究科, 准教授 (10325095)
• Research Collaborator: NAGATSUKA Hitoshi 岡山大学, 医歯(薬)学総合研究科, 教授 (70237535)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 歯根膜 / 骨髄幹細胞 / 歯周組織 / 歯髄組織 / メカニカルストレス / 歯科矯正学 / リモデリング

Outline of Final Research Achievements

We demonstrated the following results in this study.
1. Bone marrow stem cells have a potential to differentiate into dental pulp cells and periodontal ligament cells. 2. Bone marrow stem cells engraft in the active remodeling tissues. 3. There were close relations in the expression of HSPs and Neuroendocrine-related factors and bone marrow drived cell in the periodontal ligament under injurious stimuli. 4．These results can be applied to development of new orthodontic treatment and the effective treatment of the injury.

Free Research Field

口腔病理学