2016 Fiscal Year Final Research Report
Epigenetics in the postnatal development of masticatory muscles
| Project/Area Number |
26463127
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Orthodontics/Pediatric dentistry
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| Research Institution | Tsurumi University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 咀嚼筋 / 非咬合モデルマウス / 生後発達 / エピジェネティクス |
|---|
| Outline of Final Research Achievements |
The regulatory pathway of miR-1 via HDAC4 and MEF2 plays a more prominent role during postnatal development in the masseter muscle than in the gastrocnemius muscle, whereas that of miR-133a via SRF plays a more prominent role in the gastrocnemius muscle than in the masseter muscle.
MiR-1 promotes the differentiation of skeletal muscle directly through the post-transcriptional inhibition of HDAC4 expression and that miR-133a promotes the proliferation of skeletal muscle directly through the post-transcriptional inhibition of SRF expression.
MiR-1 promotes the differentiation of skeletal muscle directly through the post-transcriptional inhibition of HDAC4 expression and that miR-133a promotes the proliferation of skeletal muscle directly through the post-transcriptional inhibition of SRF expression.
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| Free Research Field |
小児歯科学
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