2016 Fiscal Year Final Research Report
Effect of IL-22 on immune response against periodontal bacteria
| Project/Area Number |
26463151
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Periodontology
|
|---|
| Research Institution | Osaka Medical College (2016)
Hyogo Medical University (2014-2015) |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2014-04-01 – 2017-03-31
|
| Keywords | IL-22 / 歯肉上皮細胞 / 細胞内侵入細菌 |
|---|
| Outline of Final Research Achievements |
This study focused on the effects of IL-22 on the response against periodontal bacteria in gingival epithelial cells. We found that IL-22 reduced gingival epithelial cell differentiation and subsequently decreased antibiotic peptide productivity. In addition, incubation with IL-22 decreased the invasion of Porphyromonas gingivalis into the gingival epithelial cells. The results suggest that IL-22 augments resistance to bacterial invasion of gingival epithelial cells.
The effect of IL-22 on immune response against periodontal bacteria.
|
| Free Research Field |
歯周病態学
|
