Evaluation of effectiveness of equol for salivary secretion and the elucidation of the action mechanism.

2016 Fiscal Year Final Research Report

• Project/Area Number: 26463198
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Social dentistry
• Research Institution: Tsurumi University
• Principal Investigator: Ryo Koufuchi 鶴見大学, 歯学部, 講師 (10298268)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: ドライマウス / イソフラボン / 女性ホルモン / エストロゲン / 口腔乾燥症 / 酸化ストレス / シェーグレン症候群 / エクオール

Outline of Final Research Achievements

Dry mouth (xerostomia) don’t make enough saliva to keep mouth wet. It is a multi-factorial disease and reduced quality of life (QOL). In addition, the disease has been reported common in menopausal women. This study was conducted to test of equol affect salivary secretion，oxidative stress markers, equol concentrations and subjective measurements.
Nine patients were given equol orally at a dosage of 10mg/day for 1 month, and salivary secretion, oxidative stress markers, equol concentrations in the urine and subjective measurements were analyzed before and after treatment. The results showed a significant improvement based on the equol and self-completed questionnaire. Subjective parameters that improved significantly after treatment score, included discomfort in teeth and mouth, constipation and white hair. The saliva flow rate results are increase after 1 month.

Free Research Field

医歯薬学