Development and evaluation a maternal and neonatal care system for prevention of group B Streptococcus disease

2018 Fiscal Year Final Research Report

• Project/Area Number: 26463420
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Lifelong developmental nursing
• Research Institution: Nagoya City University
• Principal Investigator: WAKIMOTO HIROKO 名古屋市立大学, 大学院看護学研究科, 准教授 (40336706)
• Co-Investigator(Kenkyū-buntansha): 矢野 久子 名古屋市立大学, 看護学部, 教授 (00230285) ; 長谷川 忠男 名古屋市立大学, 大学院医学研究科, 教授 (10314014) ; 佐藤 剛 名古屋市立大学, 大学院医学研究科, 講師 (80326149)
• Research Collaborator: SUZUKI satoshi ; WAKIMOTO yukio
• Project Period (FY): 2014-04-01 – 2019-03-31
• Keywords: 母子感染 / 母子感染予防 / GBS / 新生児 / 血清型 / 薬剤感受性 / CovR/S / 面接調査

Outline of Final Research Achievements

The subjects were children who developed early-onset GBS disease (EOGBSD) or late-onset GBS disease (LOGBSD) and their mothers from 5 institutes between 2007 and 2016. There were 14 cases of EOGBSD and 17 cases of LOGBSD, inborn cases were 4 cases both EOGBSD and LOGBSD, with estimated incidence of 0.10 per 1,000 live births for both EOGBSD and LOGBSD. We divided the study period into two parts; the period before (period I: 2007-2008) and after (period II: 2009-2016) issue of the guideline for prevention of vertical transmission in Japan. The incidence of EOGBS was significantly lower in period II (0.03 per 1,000 births) than in period I (0.42 per 1,000 births) (p = 0.02). The incidence of EOGBSD would further decline with proper timing of GBS screening, sampling site, culture method, and appropriate antibacterial prophylaxis for pregnant GBS carriers.

Free Research Field

医歯薬学

Academic Significance and Societal Importance of the Research Achievements

新生児側の要因と母側の要因と微生物側の要因を併せて解析し，新生児GBS感染症の発症要因を明らかにすることで，より良い周産期医療向上の一助となり，新生児GBS感染症の予防に寄与できると考える．GBS保菌妊産褥婦への必要なケアを明らかにし，ケアを講じることは，安心して子どもを産み育てることができ，周産期ケア向上の一助となる．