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2016 Fiscal Year Final Research Report

Impact and response to DNA damage in mitosis

Research Project

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Project/Area Number 26550027
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Risk sciences of radiation and chemicals
Research InstitutionKyoto University

Principal Investigator

Matsumoto Tomohiro  京都大学, 放射線生物研究センター, 教授 (80212223)

Project Period (FY) 2014-04-01 – 2017-03-31
Keywords有糸分裂期 / テロメア / 染色体凝縮
Outline of Final Research Achievements

Mitosis is a cell cycle stage in which the radiation sensitivity is higher than any other stages, but the underlying mechanisms are still unclear. In this research project, we used the fission yeast model system and found the followings:
1) Some of the stress response genes, including DNA repair gene around telomere are normally silenced. 2) This silencing requires a chromosome-condensing factor and a kinase that phosphorylates the condensing factor in mitosis. We therefore found a novel mechanism of gene silencing that likely accounts for a low activity of DNA repair in mitosis.

Free Research Field

放射線生物学

URL: 

Published: 2018-03-22  

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