Development of anti-infective agents focusing on intracellular changes in metal concentration

2016 Fiscal Year Final Research Report

• Project/Area Number: 26560453
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Chemical biology
• Research Institution: Institute of Physical and Chemical Research
• Principal Investigator: Wada Akira 国立研究開発法人理化学研究所, ライフサイエンス技術基盤研究センター, 専任研究員 (90443051)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 感染症治療薬 / マラリア原虫

Outline of Final Research Achievements

In this research, focusing on intracellular changes in metal concentration, we have tried to explore molecular ligands that could interact with metal ions used for the growth of malaria. In the result, specific molecular ligands, which could suppress the growth of chloroquine-resistant malaria parasite, have been discovered. Furthermore, on the basis of various biological assessments of the molecular ligands, we have found useful characteristics as a candidate of anti-malarial drug.

Free Research Field

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