Neural prosthesis with a geomagnetic compass

2015 Fiscal Year Final Research Report

• Project/Area Number: 26640003
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Neurophysiology / General neuroscience
• Research Institution: The University of Tokyo
• Principal Investigator: Ikegaya Yuji 東京大学, 薬学研究科(研究院), 教授 (10302613)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Keywords: 脳 / 感覚 / 大脳皮質 / 地磁気

Outline of Final Research Achievements

Allocentric sense is one of the major components that underlie spatial navigation. In blind patients, the difficulty in spatial exploration is attributed, at least partly, to the deficit of absolute direction perception. In support of this notion, we announce that blind adult rats can perform spatial tasks normally when externally provided with real-time feedback of their head directions. Head-mountable microstimulators coupled with a digital geomagnetic compass were bilaterally implanted in the primary visual cortex of adult rats whose eyelids had been sutured. These "blind" rats were trained to seek food pellets in a T-shaped maze or a more complicated maze. Within tens of trials, they learned to manage the geomagnetic information source to solve the mazes. Their performance levels and navigation strategies were similar to those of normal sighted, intact rats. Thus, blind rats can recognize self-location through extrinsically provided stereotactic cues.

Free Research Field

神経薬理学