2014 Fiscal Year Final Research Report
The effect of uterus and aging during the anterior-posterior axis formation
| Project/Area Number |
26650080
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Developmental biology
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| Research Institution | Osaka University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2015-03-31
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| Keywords | 前後軸 / 子宮 |
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| Outline of Final Research Achievements |
Vertebrates have three principal body axes; Anterior-Posterior (A-P), Dorsal-Ventral (D-V), and Left-Right (L-R) axis. In many organisms, A-P axis is the first overt body one, establishment of A-P axis is based on early molecular asymmetry and essential for later development, including the formation of other axes.The origin of the DVE is pushed back at least to the peri-implantation stage, which is much earlier than expected.
In this research, I revealed that Nodal and Lefty1 was expressed in uterus in implantation stage. These results can be guessed that A-P asymmetries is induced maternal Nodal signaling.
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| Free Research Field |
発生生物
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