2015 Fiscal Year Final Research Report
Molecular mechanisms of heat acclimation - How to prevent heat stroke
| Project/Area Number |
26650173
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Applied anthropology
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| Research Institution | Kanazawa University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
SHIDO Osamu 島根大学, 医学部, 教授 (40175386)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
|
| Keywords | 暑熱順化 / 熱中症 |
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| Outline of Final Research Achievements |
Recently, temperature of earth is increasing and heat stroke often occurs. To prevent heat stroke in the world, molecular mechanisms of heat adaptation should be revealed. In this study, we investigated the effects of heat on cells.
Heat increased heat shock proteins and aquaporins. Heat also induced tolerance of hypoxia. Interestingly, heat down-regulated TRPV1, a thermal sensor. Here, we revealed a port of molecular mechanism of heat acclimation.
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| Free Research Field |
応用人類学、環境生理学
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