Development of molecular-targeting therapy against liver metastasis of small cell lung cancer

2016 Fiscal Year Final Research Report

• Project/Area Number: 26670418
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Respiratory organ internal medicine
• Research Institution: The University of Tokushima
• Principal Investigator: NISHIOKA Yasuhiko 徳島大学, 大学院医歯薬学研究部(医学系), 教授 (70274199)
• Co-Investigator(Renkei-kenkyūsha): GOTO Hisatsugu 徳島大学, 大学院医歯薬学研究部, 講師 (00437641)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 肝転移 / 小細胞肺癌 / 予後

Outline of Final Research Achievements

In the present study, we examined the clinical significance of liver metastasis and identified the specific gene associated with liver metastasis in small cell lung cancer (SCLC). We first found the sphere-forming population of SCLC cell line SBC5 preferentially metastasized to the liver. Using these cell lines, the specific gene B associated with liver metastasis was identified. The knockdown of the gene B in SBC5 cells showed the reduction of metastasis to the liver, but not other organs. From the clinical analysis, we confirmed the association between liver metastasis and PS in SCLC patients.

Free Research Field

呼吸器内科学