2014 Fiscal Year Final Research Report
Comprehensive Analysis of the Regulation of Basophil Development
| Project/Area Number |
26670502
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pediatrics
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| Research Institution | The University of Tokushima |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
NISHIKAWA Yumiko 徳島大学, 疾患プロテオゲノム研究センター, 助教 (60448214)
WADA Takeshi 徳島大学, 疾患プロテオゲノム研究センター, 特任助教 (80583418)
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| Research Collaborator |
MINEGISHI Shizuko
INOUE Fumiko
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| Project Period (FY) |
2014-04-01 – 2015-03-31
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| Keywords | アレルギー |
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| Outline of Final Research Achievements |
Hyper-IgE syndrome is one of the primary immunodeficiency, caused by dominant negative mutations of the STAT3 gene (Minegishi et al. Nature 2007). Most of the patients with this disorder suffer from severe atopic dermatitis, but the mechanistic basis is still elusive. To elucidate a molecular mechanism, we established a model mice of this syndrome and developed an atopic dermatitis model with the mice. We found that atopic dermatitis is more severe in Stat3 dominant negative mice compared to wild-type mice. We investigate the molecular mechanism of this phenotype.
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| Free Research Field |
小児科学
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