application of high resolution arufa-autoradiography for analysing micro-distribution of B-compund in tissues and its BNCT effects

2016 Fiscal Year Final Research Report

• Project/Area Number: 26670557
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Radiation science
• Research Institution: Kyoto University
• Principal Investigator: ONO Koji 京都大学, 原子炉実験所, 寄附研究部門教員 (90122407)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: BNCT / CBEファクター / BPA / BSH / 放射線脳壊死 / 放射線肺線維症

Outline of Final Research Achievements

A new formula to describe the relation between CBE factor and B-10 level in tissue. For brain radio-necrosis, CBE=0.32+N/Bx1.65. N and B are B-10 level (ppm) in the normal brain and the blood. For BSH, it is independent of B-10 level in the tissue and a fixed value (=0.36). For lung fibrosis, CBE=0.32+N/Bx1.80. For BSH, there exsist no data for analysis.
it is independent of B-10 level in the tissue and a fixed value (=0.36).
As above analysis, B-10 level in normal brain is very important factor. An idea to selectively reduce the B-10 level was discovered when BPA was applied to BNCT. Predosing of PA (phenylalanine) prior to BPA administration markedly decreased B-10 level of brain tissue and an increase of therapetuic gain factor is expected in clinical BPA-BNCT for brain tumor.

Free Research Field

放射線腫瘍学