Changes of intestinal microbiome of preterm labor cases and endometriosis cases by metagenome analysis.

2016 Fiscal Year Final Research Report

• Project/Area Number: 26670717
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Obstetrics and gynecology
• Research Institution: University of Toyama
• Principal Investigator: SAITO Shigeru 富山大学, 大学院医学薬学研究部(医学), 教授 (30175351)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 腸内細菌叢 / 早産 / 子宮内膜症 / 炎症性疾患

Outline of Final Research Achievements

Preterm delivery and endometriosis are classified to inflammatory diseases. Recent data demonstrate that the changes of intestinal flora are correlated with inflammatory diseases by affecting immune system. Therefore, we have studied the metagenome profile in preterm labor cases and endometriosis cases. We have not found significant changes in intestinal flora, but abundance of Escherichia/Shigella was found in some preterm labor cases, and abundance of Meganonas and decreased Parabacteroides were found in some endometriosis cases. We should clarified the relationship between patients conditions and abnormality of intestinal flora.

Free Research Field

産科婦人科