Exploration of mechanisms involved in spiral artery remodeling using human induced pluripotent stem cell-derived endothelial cells

2015 Fiscal Year Final Research Report

• Project/Area Number: 26670720
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Obstetrics and gynecology
• Research Institution: Kyoto University
• Principal Investigator: Kondoh Eiji 京都大学, 医学(系)研究科(研究院), 講師 (10544950)
• Co-Investigator(Kenkyū-buntansha): MOGAMI Haruta 京都大学, 大学院医学研究科, 助教 (40378766) ; KONISHI Ikuo 京都大学, 大学院医学研究科, 教授 (90192062)
• Co-Investigator(Renkei-kenkyūsha): SONE Masakatsu 京都大学, 大学院医学研究科, 講師 (40437207)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Keywords: ヒトiPS細胞 / 血管内皮細胞 / 不死化EVT / 妊娠高血圧症候群 / 母体子宮らせん動脈リモデリング不全

Outline of Final Research Achievements

Direct-contact co-culture of human induced pluripotent stem cell-derived endothelial cells adhered to immortalized extravillous trophoblast HTR-8/ SVneo cells decreased cell cell viability of human induced pluripotent stem cell-derived endothelial cells (79.7% versus 49.7%) as well as populations of CD144 positive cells.

Free Research Field

医歯薬学・産婦人科学