Potential therapy with artificial HDL and photoresponsive nanomaterial for Age-related maculopathy

2015 Fiscal Year Final Research Report

• Project/Area Number: 26670754
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Ophthalmology
• Research Institution: Kyoto University
• Principal Investigator: GOTOH Norimoto 京都大学, 医学(系)研究科(研究院), 准教授 (20632095)
• Co-Investigator(Kenkyū-buntansha): MURAKAMI Tatsuya 京都大学, 学内共同利用施設等, 准教授 (90410737) ; KOTANI Kazuhiko 自治医科大学, 医学部, 教授 (60335510) ; TSUJIKAWA Akitaka 香川大学, 医学部, 教授 (40402846)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Keywords: 眼科学 / 加齢黄斑変性 / HDL / 遺伝子発現 / ドラッグデリバリーシステム

Outline of Final Research Achievements

(1) Establishing RNA expression profile of human choroidal neovascularization samples using next generation sequencing. (2) Developing novel transcorneal drug delivery system of artificial HDL delivery into the mouse retina. (3) Establishing modified method for evaluating HDL cholesterol efflux with small clinical samples.

Free Research Field

眼科学