Analysis of ornithine rhamnolipid-like pigment from oral bacteria

2015 Fiscal Year Final Research Report

• Project/Area Number: 26670800
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Morphological basic dentistry
• Research Institution: Osaka University
• Principal Investigator: Kawabata Shigetada 大阪大学, 歯学研究科(研究院), 教授 (50273694)
• Co-Investigator(Kenkyū-buntansha): NAKATA Masanobu 大阪大学, 大学院歯学研究科, 准教授 (90444497) ; SUMITOMO Tomoko 大阪大学, 大学院歯学研究科, 助教 (50423421) ; YAMAGUCHI Masaya 大阪大学, 大学院歯学研究科, 助教 (00714536)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Keywords: 口腔細菌 / 細菌由来色素

Outline of Final Research Achievements

Pigments are produced from numerous bacterial species. Although several pigments possess hemolytic and cytotoxic properties, their roles in virulence of bacterial pathogens is not fully appreciated. In this study, we found that GNAT (GCN5-related N-acetyltransferase) is related to ornithine rhamnolipid-like pigment synthesis of Propionibacterium acnes. Moreover, we demonstrated that the pigmentation is responsible for their hemolytic activity. P. acnes is known to be associated with sarcoidosis. Our results suggest that targeting of P. acnes pigment could serve as a novel strategy to treatment for sarcoidosis.

Free Research Field

細菌学