Development of novel anti-inflammatory therapy for apical periodontal disease using mesenchymal cell transplantation

2015 Fiscal Year Final Research Report

• Project/Area Number: 26670823
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Conservative dentistry
• Research Institution: Tohoku University
• Principal Investigator: Masahiro Saito 東北大学, 歯学研究科(研究院), 教授 (40215562)
• Co-Investigator(Kenkyū-buntansha): YOSHIDA KYOKO (今中 恭子) 三重大学, 医学研究科, 准教授 (00242967) ; KOBAYASHI YOKO (岩松 洋子) 東北大学, 大学院歯学研究科, 助教 (50261524)
• Co-Investigator(Renkei-kenkyūsha): SAITO TADAO 東北大学, 農学部, 教授 (00118358)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Keywords: 再生医療 / 細胞移植 / 抗炎症 / 細胞外マトリックス / 保存系歯学 / 動物モデル / 結合組織疾患 / 間葉系細胞

Outline of Final Research Achievements

In the present study, we attempt to develop anti-inflammatory therapy for apical periodontitis. To achieve this purposes, we investigate matricellular proteins which is a extracellular matrix involving acceleration of immune response. We found that reduced expression of fibrillin-1 that regulate tissue elasticity is excavated inflammatory response of periodontal tissue. From these findings, reduction of fibrillin-1 play an important role in the progression of apical periodontal disease.
We also established alveolar bone derived immature osteoblast obtained from human alveolar bone. These cells has a high osteogenic ability and bone forming ability in vivo. We are investigating anti-inflammatory effect of these cells.

Free Research Field

歯科保存学