2016 Fiscal Year Final Research Report
Induction of regulatory T cells by histone modification for the treatment of inflammation bowel disease
| Project/Area Number |
26713026
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Partial Multi-year Fund |
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| Research Field |
Gastroenterology
|
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| Research Institution | Toyama Prefectural University (2015-2016)
Keio University (2014) |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
|
| Keywords | 制御性T細胞 / エピジェネティクス / 短鎖脂肪酸 |
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| Outline of Final Research Achievements |
Butyrate has a potential to inhibit class I HDAC isozymes but not class II HDAC isozymes. In time course analysis, butyrate preferentially induce Foxp3, a master regulator of regulatory T cells (Treg), but not other master regulators of Th1, Th2 and Th17 (e.g., T-bet, Gata3, Ror-gamma t). Treg induction by using HDAC isozyme specific inhibitors revealed that the butyrate induce Foxp3 probably through the inhibition of HDAC1 and HDAC3 that belong to class I HDAC.
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| Free Research Field |
分子細胞生物学、免疫学
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