2015 Fiscal Year Final Research Report
Analysis of citrus-derived components focused on the defense of the hyperglycemia-induced cognitive dysfunction
| Project/Area Number |
26750058
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Eating habits
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| Research Institution | Matsuyama University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Keywords | 柑橘由来成分 / 河内晩柑 / 脳機能障害 / 高血糖 / 脳虚血 / 海馬 / 神経細胞 / タウタンパク質 |
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| Outline of Final Research Achievements |
Dried peel powder of Kawachi-bankan was orally administered to transient global cerebral ischemia mice, and microglia and astrocyte activation in the hippocampus were suppressed. Moreover, it also inhibited neuronal cell death in the hippocampus.
Kawachi-bankan dried peel powder and its contents auraptene and naringin were orally administered to streptozotocin-induced hyperglycemia mice. These mice showed hyper-phosphorylation of Tau protein in neurons in the hippocampus; however, those sample administration suppressed the Tau phosphorylation.
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| Free Research Field |
天然物薬理学
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