2015 Fiscal Year Final Research Report
Development of therapeutic drug monitoring system based on paper-based Raman spectroscopy
| Project/Area Number |
26750165
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Medical systems
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| Research Institution | Osaka University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Keywords | POCT / ラマン分光 / 薬物モニタリング |
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| Outline of Final Research Achievements |
Therapeutic drug monitoring (TDM) that can be performed near the patient is helpful for safe and effective pharmacotherapy. This study aims to realize rapid TDM that does not require blood sampling. For this purpose, paper-based Raman spectroscopy of tear fluid is proposed for on-site TDM. The paper substrates are used for tear sample collection and measurement. The use of paper offers a minimally invasive, simple, and inexpensive method for therapeutic drug monitoring. As a prototype demonstration, paper-based SERS substrates were fabricated with filter papers and gold nanorods. Experimental results show that the Raman signals of a target therapeutic drug in artificial tear fluid were enhanced with the fabricated substrates. This indicates that the proposed approach is led to on-site TDM.
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| Free Research Field |
情報フォトニクス
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