Neurocognitive Functioning in Survivors of Osteosarcoma

2017 Fiscal Year Final Research Report

• Project/Area Number: 26780410
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Clinical psychology
• Research Institution: National Center for Child Health and Development
• Principal Investigator: Sato Satomi 国立研究開発法人国立成育医療研究センター, 研究所小児がん疫学臨床研究センター, (非)研究員 (50597804)
• Project Period (FY): 2014-04-01 – 2018-03-31
• Keywords: 小児がん / 骨肉腫 / 心理アセスメント / 認知機能

Outline of Final Research Achievements

The survival rate for children with osteosarcoma has improved due to advances in treatment, including intravenous high-dose methotrexate (HD-MTX). Although HD-MTX has been associated with neurotoxic effects among survivors of childhood acute lymphoblastic leukemia (ALL) and osteosarcoma survivors received HD-MTX at cumulative dosages 4- to 5-fold greater than the children with ALL, the impact of osteosarcoma treatment on neurocognitive functioning has not been well-studied in Japan.
We evaluated the neurocognitive status of 12 children using the Wechsler Intelligence Scale for Children at baseline and annually during a 2-year follow-up period. Of the 12 children, 3 underwent the first testing one month after diagnosis and the remaining children after completion of therapy. Results from cognitive measures were converted to standardized scores using age-adjusted normative data.

Free Research Field

臨床心理学