2015 Fiscal Year Final Research Report
Exploration of mechanism of drug resisitance in cancer acidic condition and development of novel therapeutic drug
| Project/Area Number |
26830108
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Tumor therapeutics
|
|---|
| Research Institution | The University of Tokushima |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2014-04-01 – 2016-03-31
|
| Keywords | がん酸性環境 / pim2 |
|---|
| Outline of Final Research Achievements |
Tumor acidity has been known to confer drug resistance in cancers, however, therapeutic drug targetting tumor acidic microenvironment have not been developed. Pim2 was highly upregulated in myeloma cells, and SIRT1, BCRP, monocarbonic transporter were upregulated in acidic condition. Pim inhibitor improved all of these change. We explored compound library in faculty of pharmaceutical sciences,and found cucurbitacinB was one of a candidates of therapeutic drugs for targeting tumor acidic condition.
|
| Free Research Field |
がん薬物療法学
|
