2015 Fiscal Year Final Research Report
Regulation of epigenome via TCA cycle in adipocytes
| Project/Area Number |
26830136
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
System genome science
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Keywords | 代謝ネットワーク / エピゲノム / 生活習慣病 |
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| Outline of Final Research Achievements |
This study reveled that during adipogenesis, the TCA cycle enzyme IDH3, which catalyzes the synthesis of a-ketoglutarate, is induced to elevate cellular a-ketoglutarate level. The elevation of a-ketoglutarate activates histone demethylase KDM4A and facilitates histone demethylation on glycolysis genes. This, in turn, induces glycolysis genes and promotes glycolysis and lipid accumulation. These results suggest that metabolism regulates epigenome during adipogenesis.
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| Free Research Field |
エピゲノム
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