2016 Fiscal Year Final Research Report
Mechanisms underlying activation of AMPK by acetic acid in rat L6 myotube cells
| Project/Area Number |
26850087
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Food science
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| Research Institution | Okayama Prefectural University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
YAMASHITA Hiromi 岡山県立大学, 保健福祉学部・栄養学科, 教授 (70254563)
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| Research Collaborator |
MARUTA Hitomi
ARAKI Aya
ARAOKA Chihiro
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 酢酸 / L6筋管細胞 / GPR43 / AMPK / カルシウムシグナル / 骨格筋遅筋化 / ACSS3 / Propionyl-CoA synthetase |
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| Outline of Final Research Achievements |
Chronic intake of acetic acid induces the activation of AMPK in skeletal muscle, leading to the increase of slow muscle fiber and improvement of endurance performance. In this study, we investigated action mechanism of acetic acid using rat L6 myotube cells. Our data indicate that there are two mechanisms for the effect of acetic acid on the activation of AMPK in the cells. One is due to the increase in the AMP:ATP ratio via the activity of acetyl-CoA synthetase, and the other is due to activation of calcium signaling via a short-chain fatty acid receptor, GPR43. This study suggests the possibility that the intake of acetic acid cause the same effect as the exercise, increase in slow muscle fiber, and improve symptoms of sarcopenia.
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| Free Research Field |
生化学
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